MIRNA 146 AND ITS ASSOCIATION WITH AUTOIMMUNE DSEASES

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level through base-pairing predominantly with a 3-untranslated region of target mRNA, followed by mRNA degradation or translational repression. Totally, miRNAs change, complex regulatory network, more than 60% human genes. MiRNAs key regulators immune response affect maturation, proliferation, differentiation, and activation cells, as well antibody secretion release inflammatory mediators. In this review, we generally discuss miRNAs, its types role in regulation system autoimmune process, focusing on participation miRNA-146 development multiple sclerosis (MS), Rhumatoid arthritis Type-I diabetes mellitus. Disruption may lead to various pathological conditions, including inflammation. Special attention is given inflammation sclerosis, This study concluded that, dysregulation miR-146 genes was one main causes for many diseases our findings indicate significant association decreased sustained imbalance